An Inquiry into the Causes and Effects of the Variolae Vaccinae
1798
A pamphlet reporting Jenner's observation in rural Gloucestershire that dairy workers who had caught cowpox did not later catch smallpox. It presents about two dozen case histories, then his experiment: inoculating a boy, James Phipps, with matter from a cowpox sore and afterwards with smallpox matter, which produced no disease. Jenner proposes cowpox inoculation as protection against smallpox.