anthropic.com article · 6 studies · 6 UNSCIENTIFIC
Claude discovers a novel enzyme system with CRISPR-like repeats
This is an article, not a scientific study, but the article mentions studies, and those were graded.
- The study this article reportsUNSCIENTIFIC
Autonomous AI agents discover reverse transcriptases with tandem repeat arrays
This study claims that autonomous AI agents discovered a new family of reverse transcriptases in bacterial viruses that carry tandem repeat arrays upstream, producing abundant RNAs during infection.
The computers returned strings of letters and the model told them those letters were DNA sequences encoding reverse transcriptases, but a stranger looking at the same screen sees letters, not enzymes.
Where the article mentions it
Our work to understand the primary function of ARTs is ongoing. However, we think it is important to share such findings early, both to demonstrate Claude’s capabilities and to give the broader community insight into what we’re working on. We have released a pre-print (here) that discusses this in more detail.
- Linked studyUNSCIENTIFIC
A noncontiguous code for RNA-guided DNA recognition at the origin of CRISPR-Cas
This study claims that an ancient RNA-guided system uses a gapped code to recognize DNA, revealing how CRISPR immunity evolved from viruses fighting viruses.
The sequencer put out flashes of light, software turned them into letters, and the model said those letters were RNA guiding DNA. No one saw a guide touch a target.
Where the article mentions it
We are a team of scientists who have spent our careers exploring unusual proteins, and specialize in using computational approaches to systematically read DNA, interpret its evolution, and pick out biological systems for further characterization. Our research prior to joining Anthropic has helped to better understand t
- Linked studyUNSCIENTIFIC
Ring nucleases deactivate type III CRISPR ribonucleases by degrading cyclic oligoadenylate
This study claims that certain bacterial proteins switch off the bacteria's defense against viruses by chopping up the alarm molecule that turns that defense on.
The gels showed bands and the mass spectrometer showed peaks, but the model told them those bands were a ring nuclease chopping up a signaling molecule.
Where the article mentions it
We are a team of scientists who have spent our careers exploring unusual proteins, and specialize in using computational approaches to systematically read DNA, interpret its evolution, and pick out biological systems for further characterization. Our research prior to joining Anthropic has helped to better understand t
- Linked studyUNSCIENTIFIC
Bridge RNAs direct programmable recombination of target and donor DNA
This study claims that a strand of RNA can be rewritten to direct a protein to cut, paste, and flip stretches of DNA at chosen locations.
Nobody has seen DNA, let alone read a code in it; sequencing machines produce flashes of light and the model says those flashes are genetic letters.
Where the article mentions it
We are a team of scientists who have spent our careers exploring unusual proteins, and specialize in using computational approaches to systematically read DNA, interpret its evolution, and pick out biological systems for further characterization. Our research prior to joining Anthropic has helped to better understand t
- Linked studyUNSCIENTIFIC
Megabase-scale human genome rearrangement with programmable bridge recombinases
This study claims that engineered RNA-guided enzymes can rearrange the human genome by inserting, cutting out, and flipping stretches of DNA up to nearly a million letters long.
The machines produced fluorescent signals and the model told them those signals meant DNA had been rearranged, but a stranger sees signals on a screen, not rearranged DNA.
Where the article mentions it
We are a team of scientists who have spent our careers exploring unusual proteins, and specialize in using computational approaches to systematically read DNA, interpret its evolution, and pick out biological systems for further characterization. Our research prior to joining Anthropic has helped to better understand t
- Linked studyUNSCIENTIFIC
Genome modelling and design across all domains of life with Evo 2
This study claims that an AI trained on 9 trillion letters of DNA sequence can predict how genetic changes affect living things and can design new genome-scale sequences that work.
The computer produced probability numbers, and the DNA model told them those numbers meant harmful mutations and working genes.
Where the article mentions it
We are a team of scientists who have spent our careers exploring unusual proteins, and specialize in using computational approaches to systematically read DNA, interpret its evolution, and pick out biological systems for further characterization. Our research prior to joining Anthropic has helped to better understand t